Structure and Dynamics of the M3 Muscarinic Acetylcholine Receptor

Structure and dynamics of the M3 muscarinic acetylcholine receptor Andrew C Kruse 1 Jianxin Hu 2 Albert C Pan 3 Daniel H Arlow 3 Daniel M Rosenbaum 4 Erica Rosemond 2 Hillary F

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Structure and Dynamics of the M3 Muscarinic Acetylcholine Receptor

Acetylcholine the first neurotransmitter to be identified exerts many of its physiological actions via activation of a family of Gproteincoupled receptors GPCRs known as muscarinic

Importantly the M3 receptor structure allows a structural comparison between two members of a mammalian GPCR subfamily displaying different Gprotein coupling selectivities Furthermore molecular dynamics simulations suggest that tiotropium binds transiently to an allosteric site en route to the binding pocket of both receptors

Acetylcholine the first neurotransmitter to be identified exerts many of its physiological actions via activation of a family of Gproteincoupled receptors GPCRs known as muscarinic acetylcholine receptors mAChRs Although the five mAChR subtypes M1M5 share a high degree of sequence homolo

Structure And Dynamics Of The M3 Muscarinic Acetylcholine Receptor

Importantly the M3 receptor structure allows a structural comparison between two members of a mammalian GPCR subfamily displaying different Gprotein coupling selectivities Furthermore molecular dynamics simulations suggest that tiotropium binds transiently to an allosteric site en route to the binding pocket of both receptors

Structure and Dynamics of the M3 Muscarinic Acetylcholine Receptor

Molecular mechanism of muscarinic acetylcholine receptor M3 interaction

Structure and dynamics of the M3 muscarinic acetylcholine receptor

a Analysis of muscarinic receptor sequences divides them into two classesb The overall structure of the M3 receptor green is similar to that of the M2 receptor orangeThe M3bound ligand

Muscarinic acetylcholine receptor M3 M3 and its downstream effector Gq11 are critical drug development targets due to their involvement in physiopathological processes Although the structure

Structure And Dynamics Of The M3 Muscarinic Acetylcholine Receptor

Kruse AC Hu J Pan AC Arlow DH Rosenbaum DM Rosemond E et al Structure and dynamics of the M3 muscarinic acetylcholine receptor Nature 2012 Feb 234827386552556 doi 101038nature10867 Powered by Pure Scopus Elsevier Fingerprint Engine

4DAJ Structure of the M3 Muscarinic Acetylcholine Receptor RCSB PDB

The structure of the Gq11coupled M3 mAChR M3 receptor from rat bound to the bronchodilator drug tiotropium is described and a structural comparison between two members of a mammalian GPCR subfamily displaying different Gprotein coupling selectivities is allowed Acetylcholine the first neurotransmitter to be identified exerts many of its physiological actions via activation of a

a Analysis of muscarinic receptor sequences divides them into two classesb The overall structure of the M 3 receptor green is similar to that of the M 2 receptor orange The M 3bound ligand tiotropium is shown in spheres c Comparison of the intracellular surfaces shows divergence in the cytoplasmic end of transmembrane helix 5 d Comparison of the extracellular surfaces shows less

Structure and dynamics of the M3 muscarinic acetylcholine receptor

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